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LMK-235

CAS No. : 1418033-25-6

MCE 国际站：LMK-235

产品活性：LMK-235 是一种有效的，选择性的 HDAC4/5 抑制剂，可抑制 HDAC5，HDAC4，HDAC6，HDAC1，HDAC2，HDAC11 和 HDAC8 的活性，IC₅₀ 值分别为 4.22 nM，11.9 nM，55.7 nM，320 nM，881 nM，852 nM 和 1278 nM，可用于癌症研究。

研究领域：Cell Cycle/DNA Damage | Epigenetics

作用靶点：HDAC

In Vitro: LMK-235 shows cytotoxic activity against human ovarian cancer cell lines A2780 and A2780 CisR, with IC₅₀s of 0.49 µM and 0.32 µM, respectively. LMK-235 inhibits HDAC in A2780 and A2780 CisR cell lines, with IC₅₀s of 0.65 µM and 0.32 µM, respectively. LMK-235 produces a higher reduction in cell viability in comparison to the combination of cisplatin and vorinostat in all cell lines. LMK-235 (0, 0.625, 1.25, 2.5, 5, 10, and 20 µM) reduces the proliferation of BC cells in a dose- and time-dependent manner. LMK-235 (0-800 nM) also inhibits the growth of BC cells. Moreover, LMK-235 synergizes with bortezomib in BC cell lines. LMK235 (2, 20 nM) decreases in HDAC4 nuclear accumulation in Cdkl5 -/Y NPCs, completely restores the reduced number of neurons generated from Cdkl5 -/Y NPCs. LMK235 also restores histone 3 acetylation in Cdkl5 -/Y NPCs. LMK235 causes a notable increase in the isoform IV, but does not affect BDNF isoforms I or II.

In Vivo: LMK235 (5 and 20 mg/kg) restores survival and maturation of postmitotic granule neurons in Cdkl5 -/Y mice. LMK235 also restores synapse development in the dentate gyrus and hippocampus of Cdkl5 -/Y mice. Furthermore, LMK235 restores hippocampus-dependent learning and memory in Cdkl5 -/Y mice.

相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Trichostatin A | 4-Phenylbutyric acid | Valproic acid | Entinostat | Sulforaphane | Romidepsin | RGFP966 | Tasquinimod | Corin | Tacedinaline | Dacinostat | ITSA-1 | SIS17 | Tubastatin A Hydrochloride | WT-161 | Givinostat hydrochloride monohydrate | Pyroxamide | BRD-6929 | Bufexamac | HDAC8-IN-1 | Scriptaid | Sinapinic acid | Apicidin | BML-210 | M344 | Droxinostat | HDACs/mTOR Inhibitor 1 | CG347B

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