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Quinacrine dihydrochloride

CAS No. : 69-05-6

MCE 国际站：Quinacrine dihydrochloride

产品活性：Quinacrine (Mepacrine) dihydrochloride 是一种有效的，具有口服活性的抗疟剂 (antimalarial)，在体内外均具有抗肿瘤作用。Quinacrine dihydrochloride 抑制 NF-κB 并激活 p53 信号转导，诱导肿瘤细胞发生凋亡 (apoptosis)。

研究领域：Anti-infection | Apoptosis | Autophagy

作用靶点：Parasite | Apoptosis | Autophagy | Mitophagy

In Vitro: Quinacrine (5-20 µM; 24 hours) inhibits the growth of SGC⁻⁷901 cells.
Quinacrine (7.5 and 15 µM; 24 hours) induces apoptosis in SGC⁻⁷901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway.
Quinacrine (15 µM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis .

In Vivo: Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose.

相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | NF-κB Signaling Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | MG-132 | 3-Methyladenine | LY294002 | Doxorubicin hydrochloride | Bafilomycin A1 | Paclitaxel | Y-27632 dihydrochloride | SB 203580 | Chloroquine | Acetylcysteine | Angiotensin II human | Deferoxamine mesylate | SP600125 | 5-Fluorouracil | Staurosporine | Dexamethasone | Bortezomib | Metformin hydrochloride | Tamoxifen | 2-Deoxy-D-glucose | Gemcitabine | U0126-EtOH | Verteporfin | Decitabine | Actinomycin D | Temozolomide | BAY 11⁻⁷082 | Etoposide

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