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Pyridoclax

CAS No. : 1651890-44-6

MCE 国际站：Pyridoclax

产品活性：Pyridoclax 是一种 Mcl-1 抑制剂。

研究领域：Apoptosis

作用靶点：Bcl-2 Family

In Vitro: Pyridoclax directly binds to Mcl-1. Without cytotoxic activity when administered as a single agent, Pyridoclax induces apoptosis in combination with Bcl-xL-targeting siRNA or with ABT⁻⁷37 in ovarian, lung, and mesothelioma cancer cells. Pyridoclax directly binds to Mcl-1, and hence sensitizes ovarian carcinoma cells to Bcl-xL-targeting strategies. Pyridoclax induces apoptosis in ovarian, and also in lung, and mesothelioma cancer cells when it is administrated in combination with Bcl-xL-targeting siRNA or Bcl-xL targeting molecules such as ABT⁻⁷37 or its orally available derivative ABT-263.

相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Anti-Cancer Compound Library | Anti-Blood Cancer Compound Library | Venetoclax | BT2 | Chelerythrine chloride | Bax inhibitor peptide V5 | A-1210477 | BAI1 | Dehydrocorydaline chloride | Gambogic Acid | Gossypol | BI-3812 | Clitocine | PROTAC Bcl2 degrader-1 | (R)-(-)-Gossypol acetic acid | MIM1 | TW-37 | (E)-Ferulic acid | Jaceosidin | Paris saponin VII | Bz 423 | Dihydrokaempferol | MSN-125 | HA14-1 | TCPOBOP | BH3I-1 | Thevetiaflavone

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