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SSK1

CAS No. : 2629250-69-5

MCE 国际站：SSK1

产品活性：SSK1，是一种衰老特异性杀伤化合物，是一种 β-galactosidase 靶向前药，可减轻炎症。SSK1 被溶酶体 β-galactosidase 激活，并通过激活 p38 MAPK 和诱导细胞凋亡 (apoptosis) 选择性杀死衰老细胞。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: SSK1 (0.5 µM; 12⁻⁷2 hours) activates the phosphorylation levels of both p38 MAPK and MKK3/MKK6 in senescent cells. SSK1 kills senescent cells through the activation of the p38 MAPK signaling pathway. SSK1 is able to induce mitochondrial DNA damage in senescent cells.
SSK1 (0.01-1 µM; 3 days) selectively and potently eliminatesβ-galactosidase -positive senescent cells within a wide therapeutic window.

In Vivo: SSK1 (0.5 mg/kg; i.p.; two days every week; for four weeks) could eliminate senescent cells and decrease senescence-associated markers in lung-injured mice.
In aged mice (20-month-old), SSK1 (0.5 mg/kg; 3 days every 2 weeks for 8 weeks) effectively cleares senescent cells in different tissues, decreased the senescence- and age-associated gene signatures, attenuates low-grade local and systemic inflammation, and restores physical function.

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