MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

ICCB-19 hydrochloride

CAS No. : 1803605-68-6

MCE 国际站：ICCB-19 hydrochloride

产品活性：ICCB-19 hydrochloride 是一种 TRADD (TNFRSF1A associated via death domain) 抑制剂。ICCB-19 hydrochloride 与 TRADD (TRADD-N) 的 N 端结构域结合，破坏其与 TRADD-C 和 TRAF2 的结合。ICCB-19 hydrochloride 是 RIPK1 激酶活性的间接抑制剂。ICCB-19 hydrochloride 有效诱导自噬 (autophagy) 和长寿命蛋白质的降解。

研究领域：Autophagy | Apoptosis

作用靶点：Autophagy | RIP kinase | Apoptosis

In Vitro: ICCB-19 inhibits Bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 µM.
ICCB-19 has no effect on mTOR. ICCB-19 (10 µM) treatment of cells increases the levels of DsRed-FYVE dots and the lipid kinase activity of VPS34.
ICCB-19 (10 µM) promotes autophagy via K63-linked ubiquitination of beclin 1 mediated by E3 ubiquitin ligases cIAP1 and cIAP2 and the adaptor TRAF2.
ICCB-19 (10 µM) reduces the rapid activation of RIPK1 in complex I induced by TNF. Treatment with ICCB-19 increases recruitment of TRADD, HOIP, and A20, but not RIPK1, to complex I.

In Vivo: ICCB-19 reduces inflammatory responses in Tradd^−/− mice. ICCB-19 reduces expression of the TNF-induced inflammatory target gene products, NOS and COXII27, and of inflammatory cytokines in cells stimulated with pathogen-associated molecular patterns.

相关产品：MG-132 | LY294002 | Doxorubicin hydrochloride | Bafilomycin A1 | Paclitaxel | Y-27632 dihydrochloride | Acetylcysteine | Angiotensin II human | SP600125 | 5-Fluorouracil | Staurosporine | Bortezomib | Tamoxifen | 2-Deoxy-D-glucose | Gemcitabine | Necrostatin-1 | Verteporfin | Decitabine | Actinomycin D | Temozolomide | BAY 11⁻⁷082 | Etoposide | Mitomycin C | CCCP | DAPT | Rotenone | Etomoxir | Stattic | Docetaxel

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。