MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

PD-1/PD-L1-IN-NP19

CAS No. : 2377916-66-8

MCE 国际站：PD-1/PD-L1-IN-NP19

产品活性：PD-1/PD-L1-IN-NP19 是 PD-1/PD-L1 的抑制剂，抑制人类 PD-1/PD-L1 相互作用的 IC₅₀ 值为 12.5 nM。PD-1/PD-L1-IN-NP19 可以激活肿瘤的免疫微环境，这可能有助于其抗肿瘤作用。

研究领域：Immunology/Inflammation

作用靶点：PD-1/PD-L1

In Vitro: PD-1/PD-L1-IN-NP19 (compound NP19) (0.37-10 µM; 72 h) significantly elevates the production of IFN-γ in a dose dependent manner from T cells co-cultured with tumor cells.
PD-1/PD-L1-IN-NP19 exhibits much lower activity for inhibiting mouse PD-1/PD-L1 interaction with an IC₅₀ in the micromolar range (>1µM), as compared to the inhibition of human PD1/PD-L1 interaction (IC₅₀=12.5 nM).
PD-1/PD-L1-IN-NP19 (10 µM; 48 h) displays no apparent cytotoxic effects on A549, MCF⁻⁷, and B16-F10 cells at a concentration of 10 µM.

In Vivo: PD-1/PD-L1-IN-NP19 (compound NP19) (25-100 mg/kg; intragastric gavage once daily for 15 d) inhibits the growth of melanoma tumors dramatically in mice.
PD-1/PD-L1-IN-NP19 (25 mg/kg; i.p. daily for 14 d) demonstrates significant antitumor efficacy with a tumor growth inhibition (TGI) of 76.5% and is well tolerated in an H22 hepatoma mouse model.
PD-1/PD-L1-IN-NP19 (1 mg/kg; i.v.) shows the half time (t_1/2=1.5±0.5 h), clearance rate (CL=0.9±0.2 L/h/kg) and apparent distribution volume (Vss=2.1±0.5 L/kg) in rats.
PD-1/PD-L1-IN-NP19 (10 mg/kg; p.o.) shows the oral absorption (T_max=0.6±0.2 h), long half-life (t_1/2=10.9±7.7 h) and oral bioavailability (F=5%) in rats.

相关产品：Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Anti-Cancer Compound Library | Small Molecule Immuno-Oncology Compound Library | Anti-Breast Cancer Compound Library | Anti-Blood Cancer Compound Library | BMS-1 | Fraxinellone | BMS-1001 hydrochloride | Sulfamethoxypyridazine | TPP-1 | Human PD-L1 inhibitor II | Human PD-L1 inhibitor III | Human PD-L1 inhibitor IV | Human PD-L1 inhibitor V

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。