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UTL-5g

CAS No. : 646530-37-2

MCE 国际站：UTL-5g

产品活性：UTL-5g (GBL-5g) 是一种抗炎性 TNF-α 抑制剂，具有化学保护和肝脏放射保护作用。UTL-5g 通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性。

研究领域：Apoptosis

作用靶点：TNF Receptor

In Vitro: RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5g at 1, 10 or 50 µM for 60 min and then challenged with 100 ng/ml LPS. After a 16 h incubation, transcription factor activity is measured. Transcription factors that shows a UTL-5g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5g.

In Vivo: UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation.
UTL-5g (60 mg/kg; p.o.; daily for 4 days) shows positive effects in increasing the survival rates and extending the survival times.

相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Differentiation Inducing Compound Library | Orally Active Compound Library | Resatorvid | Shikonin | Fisetin | N-Formyl-Met-Leu-Phe | Adalimumab | R⁻⁷050 | QNZ | Infliximab | Muscone | SPD304 | Etanercept | Forsythoside B | Apratastat | Neochlorogenic acid | Ginsenoside Rh1 | Astilbin | Semapimod tetrahydrochloride | Sinensetin | Ginsenoside Rc | Mulberroside A | Bioymifi | DCVC | Geraniin | Homoplantaginin | Madecassic acid | Methylthiouracil | Hypaconitine | Mesaconitine | Cynaropicrin | Dexanabinol

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