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SC-236

CAS No. : 170569-86-5

MCE 国际站：SC-236

产品活性：SC-236 是具有口服活性的 COX-2 特异性抑制剂 (对 COX-1 的 IC₅₀ 值为 10 nM)和 PPARγ 激动剂。SC-236 可通过 c-Jun 氨基端抑制激活蛋白-1 (AP-1) 活性。SC-236在小鼠模型中通过抑制 ERK 的磷酸化发挥抗炎作用。

研究领域：Immunology/Inflammation | Cell Cycle/DNA Damage | Apoptosis

作用靶点：COX | PPAR | Apoptosis

In Vitro: SC-236 (15 µM, 30 min) suppresses the side effects of NSAIDs and prevented inflammation in vECs subjected to ALSS.
SC-236 significantly induces PPARγ expression in HSCs and acted as a potent PPARγ agonist in a luciferase-reporter trans-activation assay.
SC-236 strongly inhibits, in a time- and concentration-dependent manner, macrophage viability.
SC-236, either alone or in combination with 15d-PGJ2, induced a marked pro-apoptotic effect in HSCs in culture.
SC-236 mediates antitumor effect by modulation of AP-1-signaling pathway.

In Vivo: SC-236 (6 mg/kg, gavage) exhibits anti-fibrotic properties in CCl4- treated animals.

相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Anti-Cardiovascular Disease Compound Library | Pyroptosis Compound Library | Anti-Pancreatic Cancer Compound Library | MG-132 | LY294002 | Doxorubicin hydrochloride | Bafilomycin A1 | Paclitaxel | Y-27632 dihydrochloride | Acetylcysteine | Angiotensin II human | SP600125 | 5-Fluorouracil | Staurosporine | Bortezomib | Tamoxifen | 2-Deoxy-D-glucose | Gemcitabine | Verteporfin | Decitabine | Actinomycin D | Temozolomide | BAY 11⁻⁷082 | Etoposide | Mitomycin C | CCCP | Retinoic acid | DAPT | Rotenone | Etomoxir | Stattic | Docetaxel

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