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Fructosyl-lysine dihydrochloride

CAS No. : 96192-35⁻⁷

MCE 国际站：Fructosyl-lysine dihydrochloride

产品活性：Fructosyl-lysine (Fructoselysine) dihydrochloride 是葡萄糖与赖氨酸通过美拉德反应生成的一种氨基糖基化产物 (amadori glycation)。Fructosyl-lysine 是葡萄糖烷的前体，葡萄糖烷是一种赖氨酸-精氨酸蛋白交联物，可作为糖尿病中检测的指标。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: Fructosyl-lysine dihydrochloride (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [¹⁴C]fructoselysine to anionic products suggesting the existence of a fructoselysine-kinase activity in E .coli extracts.
Fructosyl-lysine dihydrochloride (100 µM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in E .coli extracts.
Fructosyl-lysine dihydrochloride (25 mM; 25 hours) lets E. coli growth at a rate of about one-third of that observed with glucose as a carbon source. Lysine itself does not support growth in the absence of other carbon source and does not affect the growth observed with glucose.

In Vivo: Fructosyl-lysine dihydrochloride and AGE residues is increased markedly in glomeruli, retina, sciatic nerve, and plasma protein in diabetic rats.

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