MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

AVE3085

CAS No. : 450348-85-3

MCE 国际站：AVE3085

产品活性：AVE3085 是一种有效的 nitric oxide synthase 增强剂，常用于心血管疾病的研究。

研究领域：Immunology/Inflammation

作用靶点：NO Synthase

In Vitro: Pre-incubation with AVE3085 restores the bradykinin-induced relaxation, reverses the decrease of p-eNOS^Ser1177, and loares the level of p-eNOS^Thr495 and nitrotyrosine. NO release in response to bradykinin is significantly reduced by ADMA and such reduction is restored by AVE3085. AVE3085 also prevents the elevation of O₂^.− and ONOO⁻ levels in coronary arteries exposed to ADMA. AVE3085 (10 µM) markedly increases ACh-induced relaxations in SHR aortae without affecting those in WKY aortae, and also increases the eNOS expression in WKY aortae.

In Vivo: AVE3085 (10 mg/kg/day, p.o.) treatment prevents the increases in the left ventricular weight, left ventricular weight/body weight ratio, mean myocyte diameter, and the expression of the hypertrophic markers ANP and β-MHC compared to the vehicle-treated mice. AVE 3085 treatment also attenuates the collagen volume fraction levels compared to the vehicle-treated mice. In the AVE3085-treated mice, the EFs, FSs, mitral E velocity, E/A ratio and LVDds are significantly improved compared to the vehicle-treated mice. AVE 3085 treatment attenuates the increase in the expression of Smad2 mRNA. Furthermore, the levels of the eNOS protein expression are significantly up-regulated in the AVE3085 group than in the vehicle-treated AB group. AVE3085 (10 mg/kg, p.o.) significantly improves ACh-induced endothelium-dependent relaxations in the aortae of SHRs, and reduces systolic blood pressure in SHRs. AVE3085 treatment for 4 weeks increases levels of p-eNOS and eNOS in SHR aortae without affecting levels of eNOS and p-eNOS in WKY aortae.

相关产品：Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Anti-Cardiovascular Disease Compound Library | Mifepristone | L-NAME hydrochloride | L-NMMA acetate | 1400W Dihydrochloride | L-Arginine | S-Nitroso-N-acetyl-DL-penicillamine | Methylene Blue | Asymmetric dimethylarginine | Isoquercetin | Chondroitin sulfate | L-NIL | Tetrahydrobiopterin | 2,4-Diamino-6-hydroxypyrimidine | Ginsenoside C-K | 6-Biopterin | Agmatine sulfate | GW274150 | Isosorbide dinitrate | L-NIO dihydrochloride | Pectolinarin | L-Canavanine sulfate | Ginsenoside Rb3 | Madecassic acid | NOC 18 | TP508 TFA | Irisflorentin | Prim-O-glucosylcimifugin | Harpagoside

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。