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Minoxidil sulfate

CAS No. : 83701-22-8

MCE 国际站：Minoxidil sulfate

产品活性：Minoxidil sulfate 是一种有效的 ATP 敏感的 K⁺ 通道 (K⁺ channel) 激动剂，是米诺地尔的硫酸代谢物。Minoxidil sulfate 被认为是一种血管扩张试剂，在动物实验模型中，促进头发生长。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Potassium Channel

In Vitro: Minoxidil sulfate (1-100 µM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.
Minoxidil sulfate (0-100 µM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.

相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Nigericin sodium salt | BAPTA-AM | Rosuvastatin Calcium | SKF-96365 hydrochloride | Glibenclamide | SCH-23390 hydrochloride | Tetrandrine | Amiodarone hydrochloride | TRAM-34 | Ifenprodil tartrate | Minoxidil | Diazoxide | 20(S)-Ginsenoside Rg3 | Senicapoc | Tannic acid | DCPIB | Astemizole | Ketanserin | Quinine | E-4031 | Terfenadine | Hydrochlorothiazide | GW9508 | Daurisoline | Nicorandil | Dofetilide | Pinacidil monohydrate | ML277 | Tolbutamide | Almitrine mesylate

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