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Z-VAD(OMe)-FMK

CAS No. : 187389-52-2

MCE 国际站：Z-VAD(OMe)-FMK

产品活性：Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) 是一种不可逆的 pan-caspase 抑制剂。Z-VAD(OMe)-FMK 是泛素 C 末端水解酶 L1 (UCHL1) 抑制剂。Z-VAD(OMe)-FMK 通过靶向 UCHL1 活性位点对 UCHL1 进行不可逆地修饰。

研究领域：Apoptosis

作用靶点：Caspase

In Vitro: Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a broad-spectrum caspase inhibitor, has been shown to inhibit the intracellular activation of caspase-like proteases. The injection of Z-VAD(OMe)-FMK suppresses the caspase-3 activity in lung tissues, and significantly decreases the number of terminal dUTP nick-end labeling-positive cells. Z-VAD(OMe)-FMK effectively inhibits UCHL1's reaction with hemagglutinin-tagged ubiquitin vinylmethyl ester (HA-UbVME) at the concentration of 100 µM. Z-VAD(OMe)-FMK is administered intraperitoneally at 1 hour before and 6 hours after SAH. Expression of caspase-3 and positive TUNEL is examined as markers for apoptosis. Z-VAD(OMe)-FMK suppresses TUNEL and caspase-3 staining in endothelial cells, decreases caspase-3 activation, reduces BBB permeability, relieves vasospasm, abolishes brain edema, and improves neurological outcome. Z-VAD(OMe)-FMK is a cell-permeable caspase inhibitor, efficiently blocks cell death induced by SMN deficiency.

In Vivo: The survival rate of mice is prolonged significantly by the injection of Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK). All mice succumbed to LPS within 30 hours. By contrast, the mice treated with Z-VAD(OMe)-FMK survive significantly longer and 27% of the mice survived more than 7 days.

相关产品：Covalent Screening Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Anti-Cancer Compound Library | Peptidomimetic Library | Covalent Screening Library | Z-VAD-FMK | Z-DEVD-FMK | Z-IETD-FMK | Tauroursodeoxycholate Sodium | Emricasan | Ac-DEVD-CHO | Guggulsterone | Wedelolactone | Z-YVAD-FMK | Ginsenoside Rh2 | Terfenadine | Dehydrocorydaline chloride | Crustecdysone | Phenoxodiol | Ac-FLTD-CMK | Asperosaponin VI | BOC-D-FMK | Taurodeoxycholic acid sodium hydrate | 2-HBA | Fenbufen | Arnicolide D | Z-WEHD-FMK | ZYZ-488 | 5,​7,​4'-​Trimethoxyflavone | Chelidonic acid | Paris saponin VII | Aristolactam I

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