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Amitriptyline hydrochloride

CAS No. : 549-18-8

MCE 国际站：Amitriptyline hydrochloride

产品活性：Amitriptyline hydrochloride 是一种血清素再摄取转运体 (SERT) 和去甲肾上腺素再摄取转运体 (NET) 抑制剂，对人的 SERT 和 NET 作用的 K_i 值分别为 3.45 nM 和 13.3 nM。Amitriptyline hydrochloride 还与多巴胺再摄取转运体 (DAT) 结合，其 K_i 为 2.58 µM。Amitriptyline hydrochloride 也抑制肾上腺素能受体 (adrenergic receptor)、毒蕈碱受体 (muscarinic receptor )、组胺受体 (histamine receptor )、5-羟色胺受体 (5-HT receptor)。Amitriptyline hydrochloride 是一种具有强神经营养活性的 TrkA 和 TrkA 受体激动剂。Amitriptyline hydrochloride 具有抗抑郁作用。

研究领域：Neuronal Signaling | GPCR/G Protein | Immunology/Inflammation | Membrane Transporter/Ion Channel | Protein Tyrosine Kinase/RTK

作用靶点：Serotonin Transporter | 5-HT Receptor | Histamine Receptor | mAChR | Adrenergic Receptor | Sodium Channel | Trk Receptor

相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Protein Tyrosine Kinase Compound Library | FDA-Approved Drug Library | CNS-Penetrant Compound Library | Drug Repurposing Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Alzheimer’s Disease Compound Library | Neuroprotective Compound Library | Drug-Induced Liver Injury (DILI) Compound Library | Clozapine N-oxide | Isoprenaline hydrochloride | Deschloroclozapine | ICI 118,551 hydrochloride | Propranolol hydrochloride | EIPA | Pilocarpine Hydrochloride | Amiloride hydrochloride | Norepinephrine | Phenylephrine hydrochloride | Monensin sodium salt | Histamine | Harmine | Atropine | Carbamazepine | SCH-23390 hydrochloride | Pimozide | Paroxetine hydrochloride | Yohimbine Hydrochloride | Fluvoxamine maleate | Puerarin | 5-(N,N-Hexamethylene)-amiloride | Olanzapine | Prazosin hydrochloride | Riluzole | ANA-12 | GTS-21 dihydrochloride

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