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Pranoprofen

CAS No. : 52549-17-4

MCE 国际站：Pranoprofen

产品活性：Pranoprofen 是一种非甾体抗炎试剂 (NSAID)，用于角膜炎或其他眼科疾病的研究。Pranoprofen 抑制 COX1/2 酶，从而阻断花生四烯酸转化为二十烷醇，减少前列腺素的合成。

研究领域：Apoptosis | Immunology/Inflammation

作用靶点：COX | Apoptosis | PGE synthase

In Vitro: Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells.
Pranoprofen (5-25 µM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 µM enhances H2O2 (800 µM)-induced Dicer expression in FHC cells.

In Vivo: Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice.
Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.

相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | Endoplasmic Reticulum Stress Compound Library | Pyroptosis Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Pancreatic Cancer Compound Library | MG-132 | LY294002 | Doxorubicin hydrochloride | Bafilomycin A1 | Paclitaxel | Y-27632 dihydrochloride | Acetylcysteine | Angiotensin II human | SP600125 | 5-Fluorouracil | Staurosporine | Bortezomib | Tamoxifen | 2-Deoxy-D-glucose | Gemcitabine | Verteporfin | Decitabine | Actinomycin D | Temozolomide | BAY 11⁻⁷082 | Etoposide | Mitomycin C | CCCP | DAPT | Rotenone | Etomoxir | Stattic | Docetaxel | Fulvestrant

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