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Tenovin-6 Hydrochloride

CAS No. : 1011301-29-3

MCE 国际站：Tenovin-6 Hydrochloride

产品活性：Tenovin-6 Hydrochloride 是 Tenovin-1 (HY-13423) 的类似物，是一种 p53 转录活性的激活剂。Tenovin-6 Hydrochloride 抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC₅₀ 分别为 21 µM、10 µM 和 67 µM。Tenovin-6 Hydrochloride 也能抑制二氢乳清酸脱氢酶 (DHODH)。

研究领域：Apoptosis | Metabolic Enzyme/Protease | Cell Cycle/DNA Damage | Epigenetics | Autophagy

作用靶点：MDM-2/p53 | Dihydroorotate Dehydrogenase | Sirtuin | Autophagy

In Vitro: Tenovin-6 Hydrochloride inhibits the growth of S. cerevisiae cultures with an IC50 of 30 µM and is more toxic to yeast than the less water-soluble tenovin-1. Tenovin-6 Hydrochloride rapidly increases the levels of endogenous K382-Ac p53 in MCF⁻⁷ cells.
Tenovin-6 Hydrochloride (0 to 15 µM) dose dependently increases the level of LC3-II in diverse cell types, and the increase is ATG5/7 dependent. Tenovin-6 Hydrochloride treatment also increases the number and intensity of autophagic vesicles with or without the presence of Torin 1, and prevents Torin 1-induced SQSTM1/p62 degradation. Tenovin-6 Hydrochloride affects the acidification of autolysosomes and impairs the hydrolytic activity of lysosomes but does not affect the fusion between autophagosomes and lysosomes. That Tenovin-6 Hydrochloride inhibits autophagy does not correlate with p53 activation and SIRT1/2 inhibition by knockdown or knockout cannot mimic the effect of Tenovin-6 Hydrochloride on LC3B accumulation.
Tenovin-6 Hydrochloride (0, 1, 2.5, 5 or 10 µM) potently inhibits cell proliferation in a dose- and time-dependent manner in all OCI-Ly1, DHL-10, U2932, RIVA, HBL1 and OCI-Ly10 cell lines. Tenovin-6 Hydrochloride consistently increases LC3B-II level in DLBCL cell lines by inhibiting the classical autophagy pathway, without activating p53, and the increase is independent of SIRT1/2/3 and p53. Tenovin-6 Hydrochloride induces apoptosis through the extrinsic cell-death pathway.
Tenovin-6 Hydrochloride suppresses the growth of UM cells with IC50 of 12.8 µM, 11.0 µM, 14.58 µM and 9.62 µM for 92.1, Mel 270, Omm 1 and Omm 2.3 cells, respectively.

In Vivo: Tenovin-6 Hydrochloride (50 mg/kg, i.p.) inhibits the growth of tumor in mice.

相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Metabolism/Protease Compound Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Antioxidants Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Ferroptosis Compound Library | Pyroptosis Compound Library | Glutamine Metabolism Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Resveratrol | Selisistat | Nicotinamide | Nicotinamide riboside chloride | Nutlin-3a | Pifithrin-α hydrobromide | 3-TYP | Eprenetapopt | Suramin sodium salt | OSS_128167 | Fisetin | Brequinar | UBCS039 | Leflunomide | Sirtinol | Amifostine | Pifithrin-µ | RITA | CAY10602 | AGK2 | MI⁻⁷73 | Pifithrin-α, p-Nitro, Cyclic | Vidofludimus | AK⁻⁷ | SIRT5 inhibitor 1 | Cambinol | MC3482

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