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Naproxen sodium

CAS No. : 26159-34-2

MCE 国际站：Naproxen sodium

产品活性：Naproxen sodium 是COX-1 和 COX-2 的抑制剂，在细胞试验中 IC₅₀ 值分别为8.72和5.15 µM。

研究领域：Autophagy | Immunology/Inflammation

作用靶点：Autophagy | COX

In Vitro: Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC₅₀s of 2.2 µg/mL and 1.3 µg/mL, respectively.

In Vivo: Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC₅₀=27, 40, 13 µM).

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