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iFSP1

CAS No. : 150651-39-1

MCE 国际站：iFSP1

产品活性：iFSP1 是 FSP1 (AIFM2) 的选择性有效抑制剂，EC₅₀ 值为 103 nM。iFSP1 可选择性地诱导过表达 FSP1 的 GPX4 敲除细胞发生铁死亡 (ferroptosis)。iFSP1 可增强多种人癌细胞系对铁死亡诱导剂的敏感度，如: (1S,3R)-RSL3 (HY-100218A)。

研究领域：Apoptosis

作用靶点：Ferroptosis

In Vitro: iFSP1 (0.001-1 µM; 24 hours) inhibits the Gpx4-knockout cell growth as a dose-dependent manner, but does not inhibit the wild type cell growth. Treatment with the ferroptosis inhibitor Lip-1 protects GPX4- knockout cells from iFSP1-induced ferroptosis.
iFSP1 (0.001-1 µM; 24 hours) is less efficient than genetic deletion of FSP1, whereas iFSP1 treatment in the FSP1-knockout background had no additive effect to RSL3-induced ferroptosis.
iFSP1 (3 µM; 24 hours) treatment results in an obvious toxicity of RSL3 in a panel of genetically engineered (FSP1-knockout) human cancer cell lines.
AIFM2: the flavoprotein apoptosis-inducing factor mitochondria-associated 2 is a previously unrecognized anti-ferroptotic gene. AIFM2, which is renamed ferroptosis suppressor protein 1 (FSP1)

相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Anti-Cancer Compound Library | Ferroptosis Compound Library | Erastin | Ferrostatin-1 | Cisplatin | Cycloheximide | RSL3 | Acetylcysteine | Deferoxamine mesylate | SP600125 | Necrostatin-1 | Rosiglitazone | SB 202190 | Curcumin | Hemin | (-)-Epigallocatechin Gallate | TBHQ | Simvastatin | Bardoxolone methyl | U⁻⁷3122 | Pifithrin-α hydrobromide | Lovastatin | Trolox | Eprenetapopt | L-Glutathione reduced | Pioglitazone | Deferiprone | NADPH tetrasodium salt | Artesunate | BAY 11⁻⁷085 | Baicalein | Sulfasalazine

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