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MitoTam iodide, hydriodide

CAS No. : 1634624⁻⁷4-0

MCE 国际站：MitoTam iodide, hydriodide

产品活性：MitoTam iodide, hydriodide 他莫昔芬衍生物，它是一种电子传递链 (ETC) 抑制剂，抑制衰老细胞中的线粒体膜电位变化并影响线粒体形态。 MitoTam iodide, hydriodide 是一种有效的抗癌剂。MitoTam iodide, hydriodide 抑制乳腺癌细胞中呼吸复合物 (CI- respiration) 和超复合物 (SCs) 的形成。 MitoTam iodide, hydriodide 可以诱导细胞凋亡 (apoptosis)。

研究领域：Apoptosis | Metabolic Enzyme/Protease

作用靶点：Apoptosis | Mitochondrial Metabolism

In Vitro: MitoTam (0.5 µM-56 µM; 24 hours) kills breast cancer cell Lines and nonmalignant cells with an IC₅₀ range from 0.65 µM to 55.9 µM.
MitoTam (2.5 µM; 2-24 hours) results in stronger activation of the apoptotic pathway in MCF7 Her2^high cells compared with mock MCF7 cells.
MitoTam (0.05 µM-1 µM; 3 days) causes a concentration-dependent induction of apoptosis in breast cancer cells, while there was no effect for non-malignant breast epithelial cells.

In Vivo: MitoTam (intraperitoneal injection; 2 µg/g; once a week; 4 weeks) decreases β-gal staining of lungs from MitoTam-treated mice, accompaning by a inhibition in the expression of senescence markers p16^Ink4a, p21^waf1 and PAI comparing control mice .
MitoTam (intraperitoneal injection; 0.54 µmol/mouse; twice a week; 2 weeks) inhibits growth of syngeneic tumors by 80%.
MitoTam (intraperitoneal injection; 0.25 µmol/mouse; twice a week; 2 weeks) slows down the growth of MCF7 mock tumors and stops tumor progression after two doses; suppresses Her2^high carcinomas decreased threefold from the original size with complete disappearance.

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