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Zoledronic Acid

CAS No. : 118072-93-8

MCE 国际站：Zoledronic Acid

产品活性：Zoledronic Acid (Zoledronate) 是第三代含氮二磷酸盐，具有高效的抗骨质再吸收活性。Zoledronic Acid 能抑制破骨细胞的分化和凋亡。Zoledronic Acid 也有抗癌作用。

研究领域：Apoptosis | Autophagy

作用靶点：Apoptosis | Autophagy

In Vitro: Zoledronic Acid (0.1-1 µM; 48 hours) increases receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells.
Zoledronic Acid increases the expression of osteoclastogenesis supporting factor from MLO-Y4 cells.
Zoledronic Acid enhances the RANKL expression via IL-6/ JAK2/STAT3 pathway in MLO-Y4 cells.
Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways.
Zoledronic Acid (10-100 µM; 1⁻⁷ days) markedly reduces the viability of MC3T3-E1 cells.
Zoledronic Acid (10-100 µM; 1⁻⁷ days) induces apoptosis in MC3T3-E1 cells.
Zoledronic Acid (10-100 µM; 4 days) inhibits cell viability due to the induction of apoptosis.
Zoledronic Acid exerts inhibitory effects on the differentiation and maturation of MC3T3-E1 cells at concentrations <1 µM.

In Vivo: Zoledronic Acid (0.05 mg/kg; i.p.; weekly; for 3 weeks) increases bone mineral density and content.
Zoledronic Acid (0.5-1 mg/kg; i.p.; weekly; for 3 weeks) inhibits both osteoclast and osteoblasts function and bone remodeling in vivo interfering with bone mechanical properties.

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