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Tenovin-1

CAS No. : 380315-80-0

MCE 国际站：Tenovin-1

产品活性：Tenovin-1 是 sirtuin 1 和 sirtuin 2 的抑制剂，同时可激活 p53，具有潜在的癌症研究的潜力。

研究领域：Apoptosis | Metabolic Enzyme/Protease | Cell Cycle/DNA Damage | Epigenetics | Autophagy

作用靶点：MDM-2/p53 | Dihydroorotate Dehydrogenase | Sirtuin | Autophagy

In Vitro: Tenovin-1 protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 targets a factor(s) upstream of p53 that not only modulates p53 function but also other cellular pathways. Tenovin-1 (10 µM) inhibits SirT2 deacetylase activity.
Tenovin-1 (1-10 µM) induces a bell-shaped concentration-dependent cell death in SK-N-MC cells. Tenovin-1 alters the gene and protein expression of Bcl-2 family members. However, Tenovin-1 has a more powerful effect both on mRNA and protein expression levels at a lower concentration than does the higher concentration. Furthermore, Tenovin-1-induced cytotoxic effects depend on caspases in p53 wild-type WE-68 cells, but not in p53 null SK-N-MC cells. AIF plays a major role in tenovin-1-induced cell death in p53 null SK-N-MC cells, but not in p53 wild-type WE-68 cells. Reactive oxygen species are also involved in tenovin-1-mediated cell death in SK-N-MC cells. In addition, Tenovin-1 causes DNA damage in SK-N-MC cells. Tenovin-1 (5 µM) increases the nuclear size in glioblastoma cells and rat primary astrocytes. Tenovin-1 induces cellular senescence, wich does not appear to be related to cell death.
Tenovin-1 (10 µM) reduces proliferation and anchorage independent growth of NSCLC cells. Tenovin-1 also inhibits cell growth of H358 lung cancer cells.

In Vivo: Tenovin-1 (92 mg/kg, i.p.) reduces growth of tumors in SCID mice derived from BL2 cells or ARN8 cells.

相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Metabolism/Protease Compound Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Antioxidants Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Ferroptosis Compound Library | Pyroptosis Compound Library | Glutamine Metabolism Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Resveratrol | Selisistat | Nicotinamide | Nicotinamide riboside chloride | Nutlin-3a | Pifithrin-α hydrobromide | 3-TYP | Eprenetapopt | Suramin sodium salt | OSS_128167 | Fisetin | Brequinar | UBCS039 | Leflunomide | Sirtinol | Amifostine | Pifithrin-µ | RITA | CAY10602 | AGK2 | MI⁻⁷73 | Pifithrin-α, p-Nitro, Cyclic | Vidofludimus | AK⁻⁷ | SIRT5 inhibitor 1 | Cambinol | MC3482

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