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Necrostatin 2

CAS No. : 852391-19-6

MCE 国际站：Necrostatin 2

产品活性：Necrostatin 2 是一种有效的程序性坏死 (necroptosis) 抑制剂。作用于TNF-α处理的FADD缺陷型Jurkat T细胞，抑制程序性坏死，EC₅₀ 为 0.05 µM。Necrostatin 2 为 RIPK1 抑制剂。

研究领域：Apoptosis

作用靶点：RIP kinase

In Vitro: Evaluation of necroptosis inhibitory activity is performed using a FADD-deficient variant of human Jurkat T cells treated with TNF-α. Utilizing these conditions the cells efficiently undergo necroptosis, which is completely and selectively inhibited by Necrostatin 2 (EC₅₀=50 nM). Necrostatin 2 shows activity in a broad range of necroptosis cellular systems. Necrostatin 2 at 30 µM completely protects L929 cells from TNF-α-induced necroptosis. In addition to TNF-α, the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD.fmk) has also been found to induce necrosis in L929 cells, which is efficiently inhibited by Necrostatin 2. EC₅₀ for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 µM.

相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Kinase Inhibitor Library | NF-κB Signaling Compound Library | Anti-Cancer Compound Library | Necrostatin-1 | GSK-872 | GSK583 | GSK840 | GSK-843 | HS-1371 | RIP2 kinase inhibitor 2 | PROTAC RIPK degrader-2 | RIPK-IN-4 | RIPK1-IN-4 | RIPK1-IN⁻⁷ | PROTAC RIPK degrader-6 | Kongensin A | GNE684 | cRIPGBM

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