MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Idasanutlin

CAS No. : 1229705-06-9

MCE 国际站：Idasanutlin

产品活性：Idasanutlin (RG7388) 是一种有效，选择性的 MDM2 拮抗剂，能够抑制 p53-MDM2 的结合，IC₅₀ 值为 6 nM。

研究领域：Apoptosis | Metabolic Enzyme/Protease

作用靶点：MDM-2/p53 | E1/E2/E3 Enzyme

In Vitro: Idasanutlin (RG7388) inhibits cell proliferation with IC₅₀ of 30 nM, and induces dose-dependent p53 stabilization, cell cycle arrest, as well as cell apoptosis in cancer cells expressing wild-type p53. Idasanutlin (RG7388) (300 nM or 1.8 µM) induces apoptosis in SJSA osteosarcoma cells.

In Vivo: Idasanutlin (RG7388, 25 mg/kg p.o.) results in tumor growth inhibition and regression, in the mouse SJSA human osteosarcoma xenograft model. Idasanutlin (RG7388) induces induction of apoptosis and antiproliferation, in the SJSA xenograft model.

相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Autophagy Compound Library | Peptidomimetic Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Oxygen Sensing Compound Library | Ubiquitination Compound Library | Ferroptosis Compound Library | Anti-COVID-19 Compound Library | Pyroptosis Compound Library | Glutamine Metabolism Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Nutlin-3a | Pifithrin-α hydrobromide | Eprenetapopt | PYR-41 | BI8622 | Ginkgolic Acid | SZL P1-41 | 2-D08 | Amifostine | Pifithrin-µ | RITA | Indole-3-carbinol | NSC232003 | BI8626 | PRT4165 | MI⁻⁷73 | Pifithrin-α, p-Nitro, Cyclic | DKM 2-93 | NSC319726 | Amifostine thiol dihydrochloride | PYZD-4409 | PK11007 | SMIP004 | Solasodine | Inauhzin | SJ-172550 | TZ9

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。