MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

BAM7

CAS No. : 331244-89-4

MCE 国际站：BAM7

产品活性：BAM7 是一种直接的选择性 BAX 激活剂，IC₅₀ 为 3.3 µM。

研究领域：Apoptosis

作用靶点：Bcl-2 Family

In Vitro: BAM7 is selective for the BH3-binding site on BAX. BAM7 activates BAX and BAX-dependent cell death. Whereas treatment with BAX or BAM7 alone has no effect on the liposomes, the combination of BAM7 and BAX yields dose-responsive liposomal release of entrapped fluorophore. BAM7 dose- and time-responsively impairs the viability of Bak^-/- MEFs that exclusively express BAX but has no effect on Bak^-/- MEFs that contain BAK but lack BAX. In contrast, standard proapoptotic stimuli such as serum withdrawal, Staurosporine and Etoposide induces an equivalent apoptotic response in Bax^-/- and Bak^-/- MEFs. As further evidence of BAM7 specificity of action, (i) BAM7 does not affect the viability of Bax^-/- Bak^-/- MEFs; (ii) ANA-BAM16, which does not bind or activate BAX, has no effect on Bak^-/- MEFs; and (iii) BAM7 selectively induces cell death of Bax^-/- Bak^-/- MEFs reconstituted with wild-type BAX but not BAXK21E , which bears the mutation that abrogates BAM7 binding.

相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Anti-Cancer Compound Library | Venetoclax | BT2 | Chelerythrine chloride | Bax inhibitor peptide V5 | A-1210477 | BAI1 | Dehydrocorydaline chloride | Gambogic Acid | Gossypol | BI-3812 | Clitocine | PROTAC Bcl2 degrader-1 | (R)-(-)-Gossypol acetic acid | MIM1 | TW-37 | (E)-Ferulic acid | Jaceosidin | Paris saponin VII | Bz 423 | Dihydrokaempferol | MSN-125 | HA14-1 | TCPOBOP | BH3I-1 | Thevetiaflavone

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。