MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Danegaptide Hydrochloride

CAS No. : 943133-81-1

MCE 国际站：Danegaptide Hydrochloride

产品活性：Danegaptide Hydrochloride (GAP-134 Hydrochloride) 是一种有效的，选择性的，具有口服活性的 gap-junction 修饰剂，具有抗心律不齐的作用。

研究领域：Cytoskeleton

作用靶点：Gap Junction Protein

In Vitro: Danegaptide (GAP-134, compound 9f; 0.01 nM-100 µM) dose dependently reduces dye uptake in cultured C6 glioma cells in a manner.

In Vivo: Danegaptide (GAP-134, compound 9f) is evaluated for in vivo efficacy in the mouse CaCl₂ model after oral administration. For doses of 5-20 mg/kg po, Danegaptide significantly prolongs the time to conduction block in mice after the infusion of CaCl₂.
Danegaptide (GAP-134) is biologically active upon oral administration at an average plasma concentration of 250 nM, and reduces atrial fibrillation in a dog model. Danegaptide has no effect on heart rate, arterial blood pressure or other electrocardiogram (ECG) parameters. Danegaptide is an effective antiarrhythmic compound in the setting of ischaemia/reperfusion-induced arrhythmogenesis in barbiturate-anesthetized, open-chest beagles.

相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Clinical Compound Library | Peptidomimetic Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Anti-COVID-19 Compound Library | Cytoskeleton Compound Library | Orally Active Compound Library | Meclofenamic acid sodium | Larazotide acetate | Tonabersat | Carbenoxolone disodium | Gap 27 | Gap 26

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。