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Montelukast sodium

CAS No. : 151767-02-1

MCE 国际站：Montelukast sodium

产品活性：Montelukast sodium 是一种有效的、选择性和具有口服活性的半胱氨酸白三烯受体 1 (Cysltr1) 拮抗剂。Montelukast sodium 可用于研究预防哮喘和肝损伤。Montelukast sodium 在肠缺血-再灌注损伤中也具有抗氧化作用，还可以减少心脏损伤。

研究领域：GPCR/G Protein

作用靶点：Leukotriene Receptor

In Vitro: Montelukast (5 µM; 1 h) inhibits APAP-induced cell damage.

In Vivo: Montelukast (3 mg/kg; oral gavage) protects against APAP-induced hepatotoxicity in mice.
Montelukast (1 mg/kg; miniosmotic pump administration) reduces the airway remodeling changes observed in OVA-treated mice and blocks the actions of cysteinyl leukotrienes (LT) C4, D4, and E4 mediated by the CysLT1 receptor.
Montelukast (1 mg/kg; miniosmotic pump administration) reduces the elevated levels of IL-4 and IL-13 found in the BAL fluid of OVA-treated mice.

相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Drug-Induced Liver Injury (DILI) Compound Library | MK-571 sodium salt | MK-886 | Zafirlukast | Pranlukast | Nedocromil | LY223982 | CP-105696 | HAMI 3379 | Leukotriene B4 | LY255283 | (S)-Verapamil hydrochloride | 5-O-Demethylnobiletin | BIIL-260 hydrochloride | Etalocib | 11-​Keto-​beta-​boswellic acid | 12S-HHT | AS-35 | Darbufelone | KP496 | RG-12525 | Veliflapon | CP-96021 hydrochloride | LM-1484 | Montelukast | Quinotolast sodium | RS-601

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