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β-Amyloid (10-35), amide

CAS No. : 181427-66⁻⁷

MCE 国际站：β-Amyloid (10-35), amide

产品活性：β-Amyloid (10-35), amide 是一种含有 26 个氨基酸的多肽，由 β-Amyloid 肽的 10-35 残基组成。β-Amyloid (10-35) 是阿尔兹海默症淀粉样斑块 (Alzheimer’s disease) 的主要组成成分。

研究领域：Neuronal Signaling

作用靶点：Amyloid-β

In Vitro: β-Amyloid (10-35) is selected based on the following considerations: (1) β-Amyloid (10-35) incorporates the core region, point mutations of which significantly obstruct fibril formation and have been used to generate inhibitors of fibrillogenesis; (2) β-Amyloid (10-35) retains the ability to add to bona fide Alzheimer’s plaques, in contrast to other truncated peptides, and forms fibrils morphologically similar to those of the full length peptide; (3) Of most importance, the full length peptide, Aβ_(1-42), is intractable for the controlled formation of fibrils from aqueous media because at the earliest time points, some of the peptide exists as an amorphous precipitate. In contrast, the use of β-Amyloid (10-35) allows the reproducible and controlled formation of fibrils from aqueous solutions, under defined conditions of pH, ionic strength, and peptide concentration and thus yields the required homogeneous fibrils.

相关产品：Deferoxamine mesylate | DAPT | β-Amyloid (25-35) | FPS-ZM1 | Colivelin TFA | Rutin | β-Amyloid (1-42), human TFA | 20(S)-Ginsenoside Rg3 | β-Amyloid (1-40) | Tolcapone | Geniposide | Ginsenoside Rg1 | Licochalcone B | β-Amyloid (1-42), rat TFA | Semagacestat | Latrepirdine dihydrochloride | β-Amyloid (42-1), human | Dihydroergocristine mesylate | Ginsenoside Re | Ginsenoside Rg2 | Hematoxylin | Notoginsenoside R1 | Hoechst 34580 tetrahydrochloride | Phenserine | Frentizole | Tramiprosate | LX2343 | Scyllo-Inositol | Aftin-4

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