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Cecropin A

CAS No. : 80451-04-3

MCE 国际站：Cecropin A

产品活性：Cecropin A 是一种由 37 个氨基酸组成的线性多肽，具有抗菌、抗肿瘤及抗炎的功效。

研究领域：Anti-infection

作用靶点：Bacterial | Antibiotic

In Vitro: Cecropin A shows anticancer activity. Cecropin A (10-50 µM) dose-dependently reduces the viability of HL-60 cells. Cecropin A (30 µM) promotes ROS production, causes mitochondrial membrane potential (Δψm) collapse, and generates morphological changes in nuclear chromatin in HL-60 cells. Cecropin A (30 µM) also leads to an early apoptosis and cuases caspase-independent cell death in HL-60 cells. Cecropin A has cytotoxicity on gram negative bacteria, including A. baumanii (CCARM 12005, CCARM 12035, CCARM 12036, CCARM 12037) with minimal inhibitory concentration (MIC) of 0.5-1 µM. Cecropin A (25 µM) significantly blocks the expression of mTNF-α, mIL-1β, and mMIP-2 mRNA and slightly inhibited the expression of mMIP-1 mRNA in RAW264.7 cells. Cecropin A (0.1, 0.25, 0.5, 1, 2.5, 5 µM) also inhibits NO production and reduces mTNF-α cytokine levels in LPS-stimulated RAW264.7 cells, and exihibits anti-inflammatory activity.

相关产品：Rapamycin | Doxorubicin hydrochloride | Bafilomycin A1 | Puromycin dihydrochloride | Cycloheximide | Chloroquine | Staurosporine | Dexamethasone | Doxycycline (hyclate) | Actinomycin D | Cyclosporin A | G-418 disulfate | 5-Azacytidine | Etoposide | Mitomycin C | CCCP | Nigericin sodium salt | Brefeldin A | Wortmannin | Resveratrol | Tunicamycin | Bleomycin sulfate | Hygromycin B | Tacrolimus | Ionomycin | Vancomycin hydrochloride | Streptozocin | Tanespimycin | Oligomycin A

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