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Melanin Concentrating Hormone, salmon

CAS No. : 87218-84-6

MCE 国际站：Melanin Concentrating Hormone, salmon

产品活性：Melanin Concentrating Hormone, salmon是最初在硬骨鱼的垂体中发现的19个氨基酸组成的神经肽，它调节食物摄入，能量平衡，睡眠状态和心血管系统。 Melanin-concentrating hormone是 SLC-1/GPR24 和 MCHR2 的配体。

研究领域：GPCR/G Protein | Neuronal Signaling

作用靶点：MCHR1 (GPR24)

In Vitro: An orphan G protein-coupled receptor (SLC-1/GPR24) has been identified as a receptor for MCH (MCHR1). MCHR2 has higher protein sequence homology to MCHR1 than any other G protein-coupled receptor. MCHR2 is specifically activated by nanomolar concentrations of MCH, binds to MCH with high affinity, and signals through Gq protein.

In Vivo: Melanin Concentrating Hormone stimulates appetite. Continuous infusion of Melanin Concentrating Hormone into the ventricular system increases food intake for 7-8 days. Intracerebroventricular infusion of Melanin Concentrating Hormone (10 µg/day) causes a slight but significant increase in body weight in mice maintained on the regular diet. Chronic stimulation of the brain Melanin Concentrating Hormone system could cause obesity in mice.

相关产品：Melanin Concentrating Hormone, salmon TFA | GW-803430 | MCH(human, mouse, rat) TFA | MCHR1 antagonist 2 | SNAP 94847 hydrochloride | TC-MCH 7c | Ac-hMCH(6-16)-NH2 | Ethyl linolenate | Neuropeptide EI, rat | [Ala17]-MCH | MCHR1 antagonist 1 | SB-568849

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