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Loureirin A

CAS No. : 119425-89⁻⁷

MCE 国际站：Loureirin A

产品活性：Loureirin A 是从龙血树中分离到的黄酮类物质，能够降低 Akt 的磷酸化，具有抗血小板聚集的作用。

研究领域：PI3K/Akt/mTOR

作用靶点：Akt

In Vitro: Loureirin A (50 µM, 100 µM) inhibits collagen-induced platelet ATP secretion and thrombin-stimulated P-selectin expression in a dose-dependent manner. Loureirin A also significantly impairs platelet spreading on immobilized fibrinogen. Loureirin A almost completely eliminates collagen-induced Akt phosphorylation at Ser473 at the dose of 100 µM, and has an additive inhibitory effect with the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets at 50 µM.

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