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Loureirin B

CAS No. : 119425-90-0

MCE 国际站：Loureirin B

产品活性：Loureirin B 是从剑叶龙血树中分离到的黄酮类化合物，为 PAI-1 的抑制剂，IC₅₀ 值为 26.10 µM；Loureirin B 同时可以抑制 K_ATP，以及 ERK、JNK 的磷酸化，具有抗糖尿病的功效。

研究领域：Metabolic Enzyme/Protease | Membrane Transporter/Ion Channel | MAPK/ERK Pathway | Stem Cell/Wnt

作用靶点：PAI-1 | Potassium Channel | ERK | JNK

In Vitro: Loureirin B enhances the relative mRNA level of Pdx-1 and MafA. Loureirin B (1, 0.1, and 0.01 µM) increases insulin secretion in Ins-1 cells. Loureirin B (0.01 µM) almost causes no toxicity on cells. Loureirin B improves the level of expressions of MafA and Pdx-1 and ATP level. Loureirin B inhibits the KATP current but increases the [Ca²⁺]i level in Ins-1 cells. Loureirin B inhibits the expression of Col1 and FN, as well as the TGF-β1-mediated up regulation of p-JNK. Loureirin B also inhibits the up regulation of p-ERK that is induced by TGF-β1. Moreover, Loureirin B inhibits the contraction of TGF-β1-stimulated fibroblasts through the down regulation of p-ERK and p-JNK. However, Loureirin B does not suppress the up regulation of p-p38 that is induced by TGF-β1. Loureirin B downregulates both mRNA and protein levels of type I collagen, type III collagen and α-smooth muscle actin in a dose dependent manner in HS fibroblasts. Loureirin B also suppresses fibroblast proliferative activity and redistributes cell cycle, but does not affect cell apoptosis.

In Vivo: Loureirin B significantly improves the arrangement and deposition of collagen fibres, decreases protein levels of ColI, ColIII and α-SMA and suppresses myofibroblast differentiation and scar proliferative activity, in a rabbit ear scar model. Loureirin B effectively inhibits TGF-β1-induced upregulation of ColI, ColIII and α-SMA levels, myofibroblast differentiation and the activation of Smad2 and Smad3, in NS fibroblasts.

相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Membrane Transporter/Ion Channel Compound Library | Metabolism/Protease Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Aging Compound Library | Reprogramming Compound Library | Diabetes Related Compound Library | Oxygen Sensing Compound Library | Glutamine Metabolism Compound Library | Flavonoids Library | SP600125 | PD98059 | Nigericin sodium salt | BAPTA-AM | Anisomycin | TBHQ | Tauroursodeoxycholate Sodium | Honokiol | Ravoxertinib | Astragaloside IV | Rosuvastatin Calcium | SKF-96365 hydrochloride | Glibenclamide | SCH-23390 hydrochloride | Piperlongumine | Tetrandrine | Guggulsterone | Amiodarone hydrochloride | Tomatidine | BIX02189 | TRAM-34 | Ifenprodil tartrate | Minoxidil | Diazoxide | FR 180204 | 20(S)-Ginsenoside Rg3 | Senicapoc | Tannic acid

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