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Protease-Activated Receptor-2, amide

CAS No. : 190383-13-2

MCE 国际站：Protease-Activated Receptor-2, amide

产品活性：Protease-Activated Receptor-2, amide (SLIGKV-NH₂) 是一种高效的蛋白酶活化受体-2 (PAR2) 活化肽。

研究领域：GPCR/G Protein

作用靶点：Protease-Activated Receptor (PAR)

In Vitro: The PAR2-activating peptides used are: SLIGKV-OH, SLIGRL-OH, SLIGKV-NH₂, SLIGRL-NH₂. The synthetic agonist peptides mimicking the tethered ligand of PAR2, Ser-Leu-Ile-Gly-Lys-Val (SLIGKV-OH), Ser-Leu-Ile-Gly-Arg-Leu (SLIGRL-OH) and their amidated forms Ser-Leu-Ile-Gly-Lys-Val-amide (SLIGKV-NH₂) Ser-Leu-Ile-Gly-Arg-Leu-amide (SLIGRL-NH₂) have also been demonstrated being able to activate the receptor without enzymatic cleavage, therefore, have been utilised as biological tools to examine physiological functions of PAR2. Protease-Activated Receptor-2, amide is one of a four family subgroup of G-protein-coupled receptors (GPCRs), called PARs. Protease-activated receptors are distinguished from other GPCRs through their unique proteolytic mechanism of activation. For PAR2, activating proteases, such as trypsin, tryptase and coagulation factors VIIa and Xa, cleave a specific extracellular amino-terminal domain of the receptor to reveal a "tethered ligand", SLIGKV- and SLIGRL- for human and mouse/rat PAR2, respectively, which subsequently interacts with the activation domain of the receptor, initiating intracellular signaling pathways. The protease-activated receptor-2 (PAR2) has been implicated in the pathogenesis of several inflammatory and autoimmune disorders, and is expressed in a wide variety of human tissues and cells. PAR2 belongs to a family of seven transmembrane domain receptor proteins that are activated by proteolysis. Enzymatic digestion exposes an N-terminus ligand sequence that binds intramolecularly to the activation site on the extracellular loop II, initiating a G-protein-mediated cell-signalling cascade and nuclear factor-kappa B (NF-κB)-regulated gene transcription.

相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Anti-Cancer Compound Library | TRAP-6 | AZ3451 | PAR-4 Agonist Peptide, amide TFA | SCH79797 dihydrochloride | ENMD-1068 hydrochloride | SLIGRL-NH2 | TFLLR-NH2(TFA) | GB-110 hydrochloride | 2-Furoyl-LIGRLO-amide | AC-55541 | FSLLRY-NH2 TFA | Protease-Activated Receptor-4 | Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA | tcY-NH2 TFA | AC-264613 | Atopaxar | PAR 4 (1-6) (TFA) | Parstatin(human) | Parstatin(mouse) | Protease-Activated Receptor-1, PAR-1 Agonist | RWJ-56110 dihydrochloride | tcY-NH2 | TRAP-6 amide

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