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Neurotensin

CAS No. : 39379-15-2

MCE 国际站：Neurotensin

产品活性：Neurotensin 是一种肠十三肽，作为有效的细胞有丝分裂原，作用于各种结肠直肠癌和胰腺癌，对神经降压素受体 (neurotensin receptor，NTR) 具有高亲和力。

研究领域：GPCR/G Protein | Neuronal Signaling

作用靶点：Neurotensin Receptor

In Vitro: Neurotensin induces the expression of MIP-2, MCP-1, IL-1β and TNFα in murine microglial cells and stimulates IL-8 secretion in a non-transformed colon epithelial cell line stably transfected with the NTR. The high-affinity NTR, a member of the G-protein coupled receptor (GPCR) family, is present in a majority of human pancreatic and colorectal cancers, suggesting that Neurotensin (NT) may act in an endocrine fashion to affect tumor growth. Acting through the NTR1, Neurotensin is known to stimulate various signal transduction pathways, including intracellular calcium ([Ca²⁺]_i), the mitogen-activated protein kinases (MAPKs), ERK and JNK, and various PKC isoforms. Treatment of HCT116 cells with Neurotensin (100 nM) significantly increases HCT116 cell migration (~3-fold) compared with vehicle treatment; pretreatment with Curcumin (10 µM) blocksthe stimulatory effect of NT on HCT116 cell migration. ctivation of MEK/ERK by NT and downstream induction of AP-1 transcription factors contributes to the proliferative effects of Neurotensin.

相关产品：Bioactive Compound Library Plus | AF40431 | Meclinertant | Neurotensin(8-13) | Kinetensin | JMV 449 acetate | NTRC-824 | Levocabastine hydrochloride | SORT-PGRN interaction inhibitor 1 | [D-Trp11]-Neurotensin | [Lys8, Lys9]-Neurotensin (8-13)

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