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GLP-1(7-36), amide acetate

CAS No. : 1119517-19-9

MCE 国际站：GLP-1(7-36), amide acetate

产品活性：GLP-1(7-36), amide acetate 是一种主要的肠道激素，在葡萄糖的刺激下，它能促使胰岛 β 细胞分泌胰岛素。

研究领域：GPCR/G Protein

作用靶点：Glucagon Receptor

In Vitro: Cells treated with phorbol 12-myristate 13-acetate for 2 h has significantly higher active GLP-1(7-36) Acetate (Human GLP-1-(7-36)-amide Acetate) concentrations in the media than those in the control. The glucose treatment also increases active GLP-1 secretion from cells in dose-dependent manner. Palmitic, oleic, linoleic or linolenic acid dose-dependently stimulated active GLP-1 secretion from cells. Active GLP-1 secretion is significantly greater with unsaturated fatty acids such as oleic, linoleic and linolenic acids than with palmitic acid. The treatment of NCI-H716 cells with CPE dose-dependently increases active GLP-1 concentrations in the media. A 37% increase is observed in active GLP-1 secretion from these cells at a concentration of 0.1 % CPE.

In Vivo: Gastric administration of glucose increases active GLP-1(7-36) amide levels in the portal blood after 10 min, followed by a marked decrease at 30 min. The gastric administration of TO also increases active GLP-1 levels after 10 min, and followed by a decrease to basal levels at 60 min. Individually, glucose and TO increase the secretion of GLP-1 in a dose-dependent manner. Furthermore, the co-administration of glucose and TO additively increase peak GLP-1 levels. CPE-administered mice have higher active GLP-1 levels in the portal blood at 10 and 30 min than those in the control mice. When glucose is administered with CPE, active GLP-1 and insulin levels in the portal blood are slightly higher in CPE-administered mice than in the control mice. High-fat diet-fed C57BL/6J mice develop hyperglycaemia and impair glucose tolerance.

相关产品：Bioactive Compound Library Plus | Exendin-4 | Liraglutide | Glucagon (1-29), bovine, human, porcine | Avexitide | Adomeglivant | GLP-1(7-37) | BETP | GLP-2(1-33)(human) | GRA Ex-25 | NNC-0640 | Cotadutide acetate | Glucagon-like peptide 1 (1-37), human TFA | Taspoglutide | GLP-1 moiety from Dulaglutide | Glucagon receptor antagonists-3 | GLP-1(7-36), amide TFA | GLP-1(9-36)amide | GLP-2(3-33) | Exendin-3/4 (59-86) | FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS | GLP-1(28-36)amide | GLP-1(32-36)amide | GLP-1R Antagonist 1 | Glucagon receptor antagonists-1 | GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS | HAEGTFT

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