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Nicotinamide N-oxide

CAS No. : 1986-81-8

MCE 国际站：Nicotinamide N-oxide

产品活性：Nicotinamide N-oxide是生物体内烟酰胺分解代谢物, 是高效选择性的CXCR2受体拮抗剂。

研究领域：GPCR/G Protein | Immunology/Inflammation | Metabolic Enzyme/Protease

作用靶点：CXCR | Drug Metabolite | Endogenous Metabolite

In Vitro: Nicotinamide is one of the forms of vitamin B₃. It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the methylation of nicotinamide by nicotinamide N-methyltransferase, which can subsequently be oxidized by aldehyde oxidase. The second enzymatic system oxidizes nicotinamide to nicotinamide N-oxide. A series of nicotinamide N-oxides is synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Compound 1 has demonstrated potent inhibition of neutrophil chemotaxis (IC₅₀=10 nM). Compound 2 is a selective antagonist of IL-8 binding (IC₅₀=110 nM) and potent inhibitor of neutrophil chemotaxis (IC₅₀=170 nM).

相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Human Endogenous Metabolite Compound Library | Small Molecule Immuno-Oncology Compound Library | Endocrinology Compound Library | Alkaloids Library | Rapamycin | 3-Methyladenine | Acetylcysteine | 5-Fluorouracil | ATP | Retinoic acid | Hydrocortisone | Docetaxel | Estradiol | Melatonin | Clozapine N-oxide | Nicotinamide | Cytarabine | Isoprenaline hydrochloride | Prostaglandin E2 | Acetaminophen | (-)-Epigallocatechin Gallate | β-Nicotinamide mononucleotide | Calcitriol | DHEA | Liothyronine | NAD+ | Luteolin | Oseltamivir acid | Thymidine | Docosahexaenoic Acid | Kaempferol | Palmitic acid | Cyclopamine | Genistein

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