MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

RFRP-3(human) TFA

CAS No. :

MCE 国际站：RFRP-3(human) TFA

产品活性：RFRP-3 TFA efficiently inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM.
Scatchard-plot analysis shows that ¹²⁵I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the K_d value and the B_max values are 0.19 nM and 1.3 pM, respectively.
RFRP-3 TFA specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (K_d= 0.19 nM).
RFRP-3 (10^-8 to 10^-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination.

研究领域：GPCR/G Protein | Neuronal Signaling

作用靶点：Neuropeptide Y Receptor

In Vitro: RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM.
Scatchard-plot analysis shows that ¹²⁵I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the K_d value and the B_max values are 0.19 nM and 1.3 pM, respectively.
RFRP-3 TFA specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (K_d= 0.19 nM).
RFRP-3 TFA (10^-8 to 10^-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination.

相关产品：Galanin (1-30), human | HT-2157 | SHA 68 | CGP71683 hydrochloride | RF9 | Neuropeptide Y (human) (TFA) | BIBO3304 TFA | Velneperit | Galanin (1-16), mouse, porcine, rat TFA | M40 | BIBP3226 TFA | BMS-193885 | Galanin Receptor Ligand M35 | Galantide | L 152804 | BIIE-0246 | Neuropeptide Y (3-36) (human, rat) | Neuropeptide Y(29-64) | RFRP-1(human) | [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA | CYM 9484 | Galanin (1-29)(rat, mouse) | GR231118 | M1145

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。