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Dihydro-β-erythroidine hydrobromide

CAS No. : 29734-68⁻⁷

MCE 国际站：Dihydro-β-erythroidine hydrobromide

产品活性：Dihydro-β-erythroidine (DHβE) hydrobromide 是一种有效竞争性的，具有口服活性的神经 nAChRs 拮抗剂。Dihydro-β-erythroidine hydrobromide 对 α4β4 和 α4β2 有选择性，IC₅₀ 分别为 0.19 和 0.37 µM。具有抗抑郁类活性。

研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling

作用靶点：nAChR

In Vivo: Dihydro-Beta-Erythroidine hydrobromide (DHβE hydrobromide; 10 nmol/0.5 µL) is infused into the respective areas prior to a systemic nicotine injection (0.2 mg/kg; SC). DHβE infused into the ventral tegmental area (VTA), nucleus accumbens (NAcc), or infralimbic (IL) cortex, but not prelimbic (PrL) cortex, attenuated nicotine-enhanced responding for a conditioned reinforcer (CRf).
The co-administration of Dihydro-Beta-Erythroidine hydrobromide (5.0 mg/kg; s.c) with nicotine (0.2 and 0.4 mg/kg; s.c.) prevents the development of conditioned taste aversions (CTAs).

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