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Orexin B, human TFA

CAS No. :

MCE 国际站：Orexin B, human TFA

产品活性：Orexin B, human (TFA) 是 Orexin 受体的内源性激动剂，与OX1和OX2结合的 K_i 值分别为 420 和 36 nM。

研究领域：GPCR/G Protein | Neuronal Signaling

作用靶点：Orexin Receptor (OX Receptor)

In Vitro: Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor.
Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC₅₀ of 36 nM in the binding assay and an EC₅₀ of 60 nM in the [Ca²⁺]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC₅₀ in the competitive binding assay and the EC₅₀ in the [Ca²⁺]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.

In Vivo: Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively.

相关产品：Bioactive Compound Library Plus | Orexin A (human, rat, mouse) | TCS-OX2-29 | GSK1059865 | SB-674042 | TCS 1102 | EMPA | SB-408124 | IPSU | SB-649868 | Orexin B, rat, mouse | Orexin receptor antagonist 2 | OXA(17-33) | [Ala11,D-Leu15]-Orexin B(human) | Orexin B, human

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