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Nicotinamide

CAS No. : 98-92-0

MCE 国际站：Nicotinamide

产品活性：Nicotinamide 是一种 B3 维生素，通过促进 NAD⁺ 氧化还原稳态和提供 NAD⁺ 作为催化非氧化还原反应的一类酶的底物，在细胞生理学中发挥重要作用。烟酰胺是 SIRT1 抑制剂。

研究领域：Metabolic Enzyme/Protease | Epigenetics | Cell Cycle/DNA Damage

作用靶点：Endogenous Metabolite | Sirtuin

In Vitro: Pretreatment with the poly (ADP-ribose) polymerase (PARP) inhibitor nicotinamide is able to prevent HCN2 cell death. When nicotinamide is added prior to t-BuOOH, it is able to prevent neuronal cell death and inhibit apoptosis. Nicotinamide-pretreated neurons have higher expression levels of inhibitors of apoptosis (IAP) genes. Nicotinamide inhibits vasoconstriction by ET. Nicotinamide also alleviates oxidative stress, which exacerbates PE and FGR.

In Vivo: Normal and streptozotocin-nicotinamide induced adult male diabetic rats receive quercetin (10, 25 and 50 mg/kg/bw) orally, and cause significant decrease in FBG and cardiac injury marker levels with increased in insulin levels. Nicotinamide improves maternal hypertension, proteinuria, and glomerular endotheliosis in RUPP mice. Moreover, nicotinamide prolongs pregnancies, and improves survival and growth of the embryos in RUPP PE mice.

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