MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Obeticholic acid

CAS No. : 459789-99-2

MCE 国际站：Obeticholic acid

产品活性：Obeticholic acid (INT⁻⁷47) 是一种有效的，选择性的和口服活性的 FXR 激动剂，EC₅₀ 为 99 nM，并具有抗胆碱和抗炎作用。Obeticholic acid 还可诱导细胞自噬 (autophagy)。

研究领域：Metabolic Enzyme/Protease | Autophagy

作用靶点：FXR | Autophagy

In Vitro: Obeticholic acid (INT⁻⁷47) increases the expression of FXR-regulated genes in rat hepatocytes. Obeticholic acid (INT⁻⁷47) reduces expression of liver JNK-1 ａnd JNK-2. Obeticholic acid (INT⁻⁷47) (256 μg/mL) shows complete inhibition of bacterial growth in all strains tested. Intestinal permeability remains unaffected after INT⁻⁷47-addition to an IFN-γ-exposed intestinal epithelium of Caco-2 cells.

In Vivo: Obeticholic acid (INT⁻⁷47) (10 mg/kg/day) completely reverted cholestasis induced by E₂17α. Administration of Obeticholic acid (INT⁻⁷47) partially prevents the impairment in total bile acid output caused by E₂17α by increasing the relative abundance of β-MCA ａnd TCDCA ａnd TDCA. Obeticholic acid (INT⁻⁷47)7 (10 mg/kg) ａnd HS increases the pulmonary congestion in the animals. INT⁻⁷47 does not improve renal pathology in the HS-fed animals. Obeticholic acid (INT⁻⁷47) (5 mg/kg) significantly increases survival in BDL rats. Obeticholic acid (INT⁻⁷47)-treated BDL rats exhibits a significant selective ileal increase in expression of pore-closing claudin-1. Ileal expression of ZO-1 is significantly up-regulated in INT⁻⁷47-treated BDL rats.

相关产品：Natural Product Like Compound Library | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Metabolism/Protease Compound Library | FDA-Approved Drug Library | Autophagy Compound Library | Drug Repurposing Compound Library | Diabetes Related Compound Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Drug-Induced Liver Injury (DILI) Compound Library | Forskolin | GW 4064 | T0901317 | Chenodeoxycholic Acid | Guggulsterone | Fexaramine | Gly-β-MCA | Androsterone | Tauro-β-muricholic acid sodium | Sevelamer hydrochloride | Glyco-Obeticholic acid | Tauro-Obeticholic acid

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。