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Biotin-Substance P

CAS No. : 87468-58-4

MCE 国际站：Biotin-Substance P

产品活性：Biotin-Substance P (Neurokinin P) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor，NK1R)

研究领域：GPCR/G Protein | Neuronal Signaling

作用靶点：Neurokinin Receptor

In Vitro: The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize ａnd resensitize, which may be associated with NK1-R endocytosis ａnd recycling. SP ａnd the NK1-R are internalized into the same clathrin immunoreactive vesicles, ａnd then sorted into different compartments. SP is intact at the cell surface ａnd in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.

相关产品：Aprepitant | Substance P | Netupitant | Senktide | Fosaprepitant dimeglumine | Maropitant | Neurokinin B TFA | SB-222200 | Vapreotide | Neurokinin A | Saredutant | Talnetant | Vofopitant | NKP608 | L⁻⁷32138 | Eprazi dihydrochloride | Y1 receptor antagonist 1 | [Sar9,Met(O2)11]-Substance P TFA | Men 10376 TFA | Substance P(1⁻⁷) TFA | GR 159897 | Neurokinin A(4-10) TFA | Osanetant

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