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Kisspeptin-10, human TFA

CAS No. :

MCE 国际站：Kisspeptin-10, human TFA

产品活性：Kisspeptin-10, human TFA 是一种血管收缩剂和血管生成抑制剂。Kisspeptin-10, human TFA 通过其受体 GPR54 来抑制肿瘤转移作用。Kisspeptin-10-GPR54 系统在胚胎肾脏发育中起重要作用。Kisspeptin-10/GPR54 信号通过 NFATc4 介导的 BMP2 表达来诱导成骨细胞分化。

研究领域：Others

作用靶点：Others

In Vitro: Kisspeptin-10 (KP-10) ａnd its receptor GPR54 are key components in the regulation of GnRH secretion in humans ａnd other mammals. Kisspeptin-10 protein binds to GPR54. Activation of Kisspeptin-10 suppresses pulmonary human melanoma ａnd Kisspeptin-10 is a metastasis suppressor in breast cancer cells.

In Vivo: Intravenous infusion of kisspeptin-10 (7.5, 35, ａnd 100 nM) induces a dose-dependent increase in LH secretion. The stimulatory effect of kisspeptin-10 (100 n nM) on LH secretion is blocked by the GnRH antagonist cetrorelix, precluding a singular action on gonadotropes. Kisspeptin-10 inhibits angiogenesis in vivo. Kp-10 inhibits tumor growth in SCID mice xenografted with human prostate cancer cells (PC-3) through inhibiting tumor angiogenesis.

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