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Nociceptin

CAS No. : 170713⁻⁷5-4

MCE 国际站：Nociceptin

产品活性：Nociceptin 是一种十七肽，为 nociceptin 受体的内源性配体，具有镇痛作用。

研究领域：GPCR/G Protein | Neuronal Signaling

作用靶点：Opioid Receptor

In Vitro: Nociceptin (1 μg/mL) significantly prevents LPS (10 ng/mL)-stimulated cell migration whereas it is ineffective when added alone. Nociceptin (1 nM-10 μM) elicits a concentration-dependent blockade of LPS-mediated cell migration, with a maximal effect at 1 ａnd 10 μM. Nociceptin counteracts LPS-induced elevation of IL-1β mRNA levels. Nociceptin (1 μM) ａnd NNC 55-0396 induce apoptotic cell death in U87 cells. Nociceptin (1 μM) counteracts LPS-induced [Ca²⁺]i increase in U87 cells via β-arrestin 2. Nociceptin counteracts the LPS-induced phosphorylation of PKC ａnd ERK in U87 cells. Nociceptin inhibits the LPS-mediated transcriptional activation of NF-kB ａnd AP-1 reporter genes.

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