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Bombesin

CAS No. : 31362-50-2

MCE 国际站：Bombesin

产品活性：Bombesin是一种最初从青蛙皮肤中分离的十四肽; 在胃泌素释放和G蛋白受体活化中起重要作用。

研究领域：GPCR/G Protein

作用靶点：Bombesin Receptor

In Vitro: Bombesin is a tetradecapeptide with a COOH terminus ending in Gly-His-Leu-Met-NH2 ａnd subsequently is shown to closely resemble two mammalian bombesin -related peptides, gastrin-releasing peptide (GRP) ａnd neuromedin B (NMB). Bombesin is found to have stimulatory effects upon gastric ａnd pancreatic secretions, release of gastrointestinal hormones, gallbladder contraction ａnd bronchoconstriction. It is present in amphibian gastric endocrine cells, avian proventriculus endocrine cells ａnd avian brain. In mammals it is present mainly in nerve cells ａnd fibers. The only mammalian endocrine cell shown to date to have bombesin is the P-cell in fetal lung. Bombesin is also found in mammalian brain, with its highest concentration in the hypothalamus. Bombesin is shown to be a potent mitogen for Swiss 3T3 cells. In the presence of a low concentration (3.5%) of serum, bombesin stimulates 3T3 cell proliferation. In serum-free medium, bombesin induces DNA synthesis in the absence of any other added growth factor (IC₅₀=1 nM).

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