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Cibinetide

CAS No. : 1208243-50-8

MCE 国际站：Cibinetide

产品活性：Cibinetide (ARA290) 是一种 EPO 衍生物，为特异性的 erythropoietin/CD131 heteroreceptor 的激动剂，常用于神经系统疾病研究。

研究领域：Others

作用靶点：Others

In Vitro: Cibinetide (ARA290) enhances the proliferation, migration, ａnd resistance to H₂O₂-induced apoptosis of endothelial colony-forming cells (ECFCs). Cibinetide (ARA290) is an EPO-analog peptide without hematopoietic side-effects but may have neurotrophic ａnd antidepressant effects.

In Vivo: After ECFC transplantation to mice with CLI, a single Cibinetide (ARA290) injection enhances the ischemic/non-ischemic ratio of hindlimb blood flow ａnd capillary density after 28 days ａnd the homing of radiolabeled transplanted cells to the ischemic leg 4 h after transplantation. Cibinetide (ARA290; 30 μg/kg, s.c.) prevents progressive worsening of glucose control without affecting body weight of rats. Cibinetide significantly decreases glucose AUCs in IPGTT in GK rats. Low-dosage Cibinetide (35 μg/kg, i.p.) treatment only slightly attenuates the EAE severity in rats. Cibinetide-treating group (70 μg/kg, i.p.) significantly delays the onset, decreases the neurologic severity ａnd shortens the duration of EAE in a dose-dependent way.

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