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Glucose-6-phosphate dehydrogenase, Microorganism

MCE 国际站：Glucose-6-phosphate dehydrogenase, Microorganism

品牌：MedChemExpress (MCE)

货号：HY-125863

CAS：9001-40-5

中文名称：6-磷酸葡萄糖脱氢酶, 微生物

Synonyms：G6PD

存储条件：请按照分析证书中建议的条件储存产品。

运输条件：美国大陆的室温；其他地方可能有所不同。

产品活性：Glucose-6-phosphate dehydrogenase, Microorganism 是戊糖磷酸途径的限速酶。Glucose-6-phosphate dehydrogenase, Microorganism 是抗氧化途径、一氧化氮合酶、NADPH 氧化酶、细胞色素 p450 等系统中 NADPH 的主要来源。Glucose-6-phosphate dehydrogenase, Microorganism 可用于糖尿病、内皮功能障碍、癌症和心肌病等领域的研究。

体外：Glucose-6-phosphate dehydrogenase 活性可被高浓度 D-Glucose (HY-B0389) (5.6 和 25mM，72 小时) 抑制，导致 MIN6 细胞中 ROS 及细胞凋亡增加，细胞增殖及胰岛素分泌减少[2]。 Glucose-6-phosphate dehydrogenase 活性可被 Aldosterone (HY-113313) (1-100 nM，24 小时) 抑制，导致血管反应性受损和内皮功能障碍[3]。 在转染了 G6PD cDNA 的 NIH 3T3 细胞中，由 G6PD 过表达产生的 Glucose-6-phosphate dehydrogenase 会诱导肿瘤发生，且其致瘤特性与 Glucose-6-phosphate dehydrogenase 活性正相关[5]。 Glucose-6-phosphate dehydrogenase 活性在较低的金属离子 (Cu2+, Al3+, Zn2+, and Cd2+) 浓度下增强 (0.025-0.1 μM，2 小时)，而在较高的金属浓度下 (0.2 和 0.4 μM，2 小时) 减弱[6]。 NADPH (0.01-0.05 mM) 以非竞争性方式抑制 Glucose-6-phosphate dehydrogenase，Ki 值为 0.144 mM[6]。 MCE尚未独立证实这些方法的准确性。仅供参考。

体内：与野生型小鼠相比，G6PD 基因缺陷小鼠模型中葡萄糖水平显著升高，胰岛素分泌量显著降低[2]。 与 Glucose-6-phosphate dehydrogenase 正常表达的心肌病小鼠模型相比，Glucose-6-phosphate dehydrogenase 缺乏可预防心肌病小鼠模型中的心脏肥大和心肌细胞中的蛋白质聚集 (通过将 hR120GCryAB 转基因心肌病模型与 G6PD 基因缺陷模型杂交，获得Glucose-6-phosphate dehydrogenase 活性降低的 hR120GCryAB 转基因心肌病小鼠模型)[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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参考文献：

[1]. Stanton RC. Glucose-6-phosphate dehydrogenase, NADPH, and cell survival. IUBMB Life. 2012 May;64(5):362-9.
[2]. Zhang Z, et al. High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J. 2010 May;24(5):1497-505.
[3]. Leopold JA, et al. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med. 2007 Feb;13(2):189-97.
[4]. Rajasekaran NS, et al. Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell. 2007 Aug 10;130(3):427-39.
[5]. Kuo W, et al. Human glucose-6-phosphate dehydrogenase (G6PD) gene transｆorms NIH 3T3 cells and induces tumors in nude mice. Int J Cancer. 2000 Mar 15;85(6):857-64.
[6]. Sun L, et al. Kinetic properties of glucose 6-phosphate dehydrogenase and inhibition effects of several ｍmbedl ions on enzymatic activity in vitro and cells. Sci Rep. 2024 Mar 9;14(1):5806.