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Trimetazidine dihydrochloride

MCE 国际站：Trimetazidine dihydrochloride

品牌：MedChemExpress (MCE)

货号：HY-B0968

CAS：13171-25-0

中文名称：盐酸曲美他嗪

Synonyms：盐酸曲美他嗪

纯度：99.91%

存储条件：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

运输条件：美国大陆的室温；其他地方可能有所不同。

产品活性：Trimetazidine dihydrochloride 是一种选择性的长链 3-ketoyl coenzyme A thiolase 抑制剂，IC50 值为 75 nM，可抑制游离脂肪酸的 β-氧化。Trimetazidine dihydrochloride 是一种有效的抗心绞痛药和一种细胞保护药，具有抗氧化，抗炎，抗伤害和胃保护作用。Trimetazidine dihydrochloride 诱导自噬，还是一种 HADHA 抑制剂。

体外：曲美他嗪（1 μM-100 μM；24小时；HUVECs）能以一定的剂量依赖性方式增强氧化损伤的HUVECs活力[1]。MCE尚未独立证实这些方法的准确性。仅供参考。

体内：曲美他嗪（5-20 mg/kg；口服；1小时；瑞士白化雄性小鼠）10 mg/kg和20 mg/kg剂量显著提高小鼠增加电流电击癫痫（ICES）试验中的癫痫阈值电流[5]。MCE尚未独立证实这些方法的准确性。它们仅供参考。

热销产品：Estrone | 2,4-Diamino-6-hydroxypyrimidine | Avatrombopag | 5-Hydroxytryptophan | SH-4-54 | Chorionic gonadotrophin | Crenolanib | Alkaline phosphatase | Haloperidol | DSPE-PEG2000-Mal (ammonium)

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参考文献：

[1]. Shenghu He, et al. Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation. Journal of Geriatric Cardiology, December 2008 , Vol 5 No 4. [2]. Chrusciel P, et al. Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure ａnd peripheral artery disease. Drugs. 2014 Jun;74(9):971-80. [3]. Kantor PF, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000 Mar 17;86(5):580-8. [4]. Hossain F, et al.Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells ａnd Enhances Cancer Therapies. Cancer Immunol Res. 2015 Nov;3(11):1236-47. [5]. Jain S, et al. Trimetazidine exerts protection against increasing current electroshock seizure test in mice. Seizure. 2010 Jun;19(5):300-2.