ALX-5407 (hydrochloride)

MCE 国际站：ALX-5407 (hydrochloride)

CAS：200006-08-2

品牌：MedChemExpress (MCE)

存储条件：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性：ALX-5407 ((R)-NFPS) hydrochloride 是一种选择性、具有口服活性的甘氨酸转运体 GlyT1 抑制剂，IC50 值为 3 nM。ALX-5407 hydrochloride 可用于研究 N-methyl-D 天冬氨酸受体功能与精神分裂症。

体外：ALX-5407 hydrochloride (0-1 mM) GlyT1- 或 GlyT2- 依赖地抑制甘氨酸转运，阻断大鼠大脑和 QT6-1C 细胞中 [3H] 甘氨酸的摄取，IC50 值为 3 nM
[1]。 ALX-5407 hydrochloride (50 nM) 在 QT6-1C 细胞中表现出缓慢的解离动力学
[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：ALX-5407 hydrochloride (1 和 10 mg/kg；口服，一次) 增加大鼠前额叶皮层游离甘氨酸水平
[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling

作用靶点：GlyT

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参考文献：
[1]. Atkinson BN, et al. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60(6):1414-20.

原创作者：MedChemExpress