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离子霉素钙盐

CAS No. : 56092-82-1

MCE 国际站：Ionomycin calcium

产品活性：Ionomycin calcium (SQ23377 calcium) 是一种有效的，选择性的钙离子载体 (calcium ionophore)，也是一种由 Streptomyces conglobatus 产生的抗生素。Ionomycin calcium (SQ23377 calcium) 对二价阳离子具有高度特异性 (Ca>Mg>Sr=Ba)。Ionomycin (SQ23377) 促进细胞凋亡。Ionomycin calcium (SQ23377 calcium) 还诱导蛋白激酶C (PKC) 激活。

研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Epigenetics | TGF-beta/Smad | Anti-infection | Apoptosis

作用靶点：Calcium Channel | PKC | Bacterial | Apoptosis | Antibiotic

结构分类：抗生素 | 其他类

In Vitro: Ionomycin is a Calcium ionophore ａnd an antibiotic produced by Streptomyces conglobatus.
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca²⁺ concentration from 50 to 180 nM. DNA ａnd protein analysis in Ionomycin-treated cultures revealed DNA fragmentation ａnd PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment.
Ionomycin-mediated cleavage ａnd exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment.

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