交换名片

(20R)-Ginsenoside Rg3 | (20R)-人参皂苷Rg3

MCE 国际站：(20R)-Ginsenoside Rg3

中文名：(20R)-人参皂苷Rg3

CAS：38243-03-7

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性： (20R)-ginsenoside Rg3 ((20R)-Propanaxadiol)，人参根中存在的活性化合物之一，可抑制血管内皮生长因子 (VEGF)(IC ₅₀=10 nM) 和抗肿瘤活性^[1]^[2]。

体外：(20R)-ginsenoside Rg3 抑制人脐静脉内皮细胞 (HUVEC) 增殖，IC50 为 10 nM
[1]。无论存在或不存在 20 ng/mL VEGF，(20R)-ginsenoside Rg3 也会剂量依赖性地抑制基质胶上 HUVEC 毛细管的形成
[1]。在大鼠主动脉环实验中，(20R)-ginsenoside Rg3 显着减弱 VEGF 诱导的 HUVEC 化学侵袭和离体微血管萌芽
[1]。在体内基质胶塞测定中(20R)-ginsenoside Rg3 （150 和 600 nM）显着消除碱性成纤维细胞生长因子 (bFGF) 诱导的血管生成
[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：(20R)-ginsenoside Rg3 （0.05-0.5 mg/kg；鼻内给药；持续 2 周）通过鼻内给药在小鼠中显示出抗疲劳作用
[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Kunming mice weighing 18-22 g
[2] Dosage: 0.05 mg/kg, 0.1 mg/kg, 0.5 mg/kg (5 μL each nostril) Administration: Intranasal administration; for 2 weeks Result: Significantly prolonged the weight-loaded swimming time, ａnd also increased the hepatic glycogen levels.

研究领域：Others

作用靶点：Others

参考文献：
[1]. Yue PY, et al. The angiosuppressive effects of 20(R)- ginsenoside Rg3. Biochem Pharmacol. 2006 Aug 14;72(4):437-45.
[2]. Wenyan Tang, et al. The anti-fatigue effect of 20(R)-ginsenoside Rg3 in mice by intranasally administration. Biol Pharm Bull. 2008 Nov;31(11):2024-7.