Resibufogenin | 酯蟾毒配基

MCE 国际站：Resibufogenin

中文名：酯蟾毒配基

CAS：465-39-4

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Resibufogenin 是华蟾素的一种成分，已被证明对癌细胞具有抗增殖作用，这可能归因于 GSK-3β 激活引起的细胞周期蛋白 D1 的降解。 IC50 值： 目标： 体外：研究了 Resibufogenin 对大鼠海马神经元外向延迟整流钾电流 (IK) 和外向瞬时钾电流 (IA) 的影响，在 1 μM 浓度 RBG 时，它抑制 IK 和 IA可以改变 IK 的一些通道动力学和门控特性，例如稳态激活和失活曲线、开放概率和时间常数
[1]。体内试验：Resibufogenin 阻止了“先兆子痫”大鼠的氧化应激证据
[2]。

热销产品：Succinyl-Coenzyme A (sodium) | Dovitinib | Vilanterol (trifenatate) | Vitamin K1 | Enfortumab | Burosumab | 1400W (Dihydrochloride) | Sunitinib (Malate) | ZM241385 | BPK-21

研究领域：Others

作用靶点：Others

热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸

Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides

参考文献：
[1]. Hao S, et al. Effects of Resibufogenin ａnd Cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampal neurons. Toxicol In Vitro. 2011 Dec;25(8):1644-53.
[2]. Uddin MN, et al. Resibufogenin administration prevents oxidative stress in a rat model of human preeclampsia. Hypertens Pregnancy. 2012;31(1):70-8.
[3]. Ichikawa M, et al. Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. PLoS One. 2015 Jun 29;10(6):e0129851.
[4]. Hao S, et al. Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons. Neurosci Lett. 2011 Aug 26;501(2):112-6.
[5]. Zheng J, et al. Novel microbial transformation of resibufogenin by Absidia coerules. Nat Prod Commun. 2011 Nov;6(11):1581-4.
[6]. Xin XL, et al. Novel microbial transformation of resibufogenin by Fusarium solani. J Asian Nat Prod Res. 2011 Sep;13(9):831-7.